Isidingo zokwelapha
I-COVID-19 ibangelwa ukutheleleka ngegciwane lesandulela ngculaza i-SARS-CoV-2, elingena futhi lingene kumaseli aphethe ngephrotheni yayo eyi-spike.Njengamanje, kunamacala abhaliwe angaphezu kwezigidi eziyi-138.3 emhlabeni jikelele, kanti inani lokufa lisondela ezigidini ezintathu.
Yize imithi yokugoma igunyaziwe ukuthi isetshenziswe ezimeni eziphuthumayo, ukusebenza kwayo kokunye kwezinhlobonhlobo ezintsha kubatshaziwe.Ngaphezu kwalokho, ukutholakala kokugoma okungenani okungama-70% abantu kuwo wonke amazwe omhlaba kungenzeka kuthathe isikhathi eside, kucatshangelwa ijubane lamanje lokugoma, ukushoda ekukhiqizweni kokugoma, kanye nezinselele zokwenziwa komsebenzi.
Umhlaba usazodinga izidakamizwa ezisebenzayo neziphephile, ngakho-ke, ukungenelela ekuguleni okubi okubangelwa yileli gciwane.Ukubuyekezwa kwamanje kugxile emsebenzini ngamunye kanye ne-synergistic ye-curcumin kanye ne-nanostructures ngokumelene negciwane.

Isidingo zokwelapha
I-COVID-19 ibangelwa ukutheleleka ngegciwane lesandulela ngculaza i-SARS-CoV-2, elingena futhi lingene kumaseli aphethe ngephrotheni yayo eyi-spike.Njengamanje, kunamacala abhaliwe angaphezu kwezigidi eziyi-138.3 emhlabeni jikelele, kanti inani lokufa lisondela ezigidini ezintathu.
Yize imithi yokugoma igunyaziwe ukuthi isetshenziswe ezimeni eziphuthumayo, ukusebenza kwayo kokunye kwezinhlobonhlobo ezintsha kubatshaziwe.Ngaphezu kwalokho, ukutholakala kokugoma okungenani okungama-70% abantu kuwo wonke amazwe omhlaba kungenzeka kuthathe isikhathi eside, kucatshangelwa ijubane lamanje lokugoma, ukushoda ekukhiqizweni kokugoma, kanye nezinselele zokwenziwa komsebenzi.
Umhlaba usazodinga izidakamizwa ezisebenzayo neziphephile, ngakho-ke, ukungenelela ekuguleni okubi okubangelwa yileli gciwane.Ukubuyekezwa kwamanje kugxile emsebenzini ngamunye kanye ne-synergistic ye-curcumin kanye ne-nanostructures ngokumelene negciwane.

I-Curcumin
I-Curcumin iyinhlanganisela ye-polyphenolic ehlukanisiwe ne-rhizome yesitshalo se-turmeric, i-Curcuma longa.Yakha i-curcuminoid enkulu kulesi sitshalo, ku-77% wesamba, kuyilapho i-curcumin II ehlanganisiwe encane yenza u-17%, kanti i-curcumin III yakha u-3%.
I-Curcumin iye yabonakala futhi yafundwa kahle, njenge-molecule yemvelo enezici zokwelapha.Ukubekezelelana nokuphepha kwayo kubhalwe kahle, ngomthamo omkhulu we-12 g / ngosuku.
Ukusetshenziswa kwayo kuchazwe njenge-anti-inflammatory, anticancer, ne-antioxidant, kanye ne-antiviral.I-Curcumin iphakanyiswe njenge-molecule enamandla okuphulukisa i-pulmonary edema nezinye izinqubo ezilimazayo eziholela ku-lung fibrosis elandela i-COVID-19.

I-Curcumin ivimbela ama-enzyme egciwane
Lokhu kucatshangwa ukuthi kungenxa yekhono layo lokuvimbela igciwane ngokwalo, kanye nokulinganisa izindlela zokuvuvukala.Ilawula ukulotshwa kwegciwane kanye nokulawula, ibophezela ngamandla aphezulu ku-enzyme ye-viral main protease (Mpro) eyisihluthulelo sokuphindaphinda futhi ivimbele ukunamathela kwegciwane kanye nokungena kuseli lomsingathi.Kungase futhi kuphazamise izakhiwo zegciwane.
Izinhlobo zayo ezihlosiwe zokulwa namagciwane zihlanganisa igciwane le-hepatitis C, i-human immunodeficiency virus (HIV), igciwane le-Epstein-Barr kanye negciwane lomkhuhlane A.Kubikwe ukuthi kuvimbela i-3C-like protease (3CLpro) ngempumelelo kakhulu kuneminye imikhiqizo yemvelo, okuhlanganisa i-quercetin, noma izidakamizwa ezifana ne-chloroquine ne-hydroxychloroquine.
Lokhu kungavumela ukuncishiswa kwemithwalo yegciwane ngaphakathi kwengqamuzana lomuntu ngokushesha kakhulu kunezinye izidakamizwa ezivimbelayo, futhi ngaleyo ndlela kuvimbele ukuqhubekela phambili kwesifo ku-acute Respiratory Distress Syndrome (ARDS).
Iphinde ivimbele i-papain-like protease (PLpro) ene-50% inhibitory concentration (IC50) ye-5.7 µM edlula i-quercetin neminye imikhiqizo yemvelo.

I-Curcumin ivimbela i-host cell receptor
Igciwane linamathela esamukeli seseli esiqondiswe kumuntu, i-angiotensin-converting enzyme 2 (ACE2).Ucwaningo lokumodela lubonise ukuthi i-curcumin ivimbela lokhu kusebenzisana kwe-virus-receptor ngezindlela ezimbili, ngokuvimbela kokubili amaprotheni e-spike kanye ne-ACE2 receptor.
Kodwa-ke, i-curcumin ine-bioavailability ephansi, ngoba ayincibiliki kahle emanzini futhi ayizinzile emithonjeni yamanzi, ikakhulukazi ku-pH ephakeme.Lapho iphuzwa ngomlomo, ingena ngokushesha emathunjini nesibindi.Lesi sithiyo singanqotshwa ngokusebenzisa ama-nanosystems.
Izithwali eziningi ezihlukene ze-nanostructured zingase zisetshenziselwe le njongo, njenge-nanoemulsions, microemulsions, nanogels, micelles, nanoparticles kanye nama-liposomes.Izithwali ezinjalo zivimbela ukuwohloka kwe-metabolic ye-curcumin, zikhuphule ukuncibilika kwayo futhi zisize ukuthi ihambe ngolwelwesi lwebhayoloji.
Imikhiqizo emithathu noma ngaphezulu ye-curcumin esekwe ku-nanostructure isivele itholakala ngokwentengiso, kodwa zimbalwa izifundo ezihlole ukusebenza kwayo ngempumelelo kwe-COVID-19 in vivo.Lokhu kubonise ikhono lezinto zokwakheka ukushintshanisa ukuphendula kwamasosha omzimba kanye nokunciphisa izimpawu zesifo, futhi mhlawumbe ukusheshisa ukululama.